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Ruthenium-Catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study

Jicheng Wu, Wenbo Xu, Zhi-Xiang Yu* and Jian Wang*

*College of Chemistry, Peking University, Beijing 100871; School of Medicine, Tsinghua University, Beijing 100084, China, Email:,

J. Wu, W. Xu, Z.-X. Yu, J. Wang, J. Am. Chem. Soc., 2015, 137, 9489-9495.

DOI: 10.1021/jacs.5b06400 (free Supporting Information)

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A ruthenium-catalyzed formal dehydrative [4 + 2] cycloaddition of enamides and alkynes enables a mild and economic construction of a broad range of highly substituted pyridines. The reaction tolerates many functional groups and offers excellent regioselectivities.

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ID: J48-Y2015