Ruthenium-Catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study
Jicheng Wu, Wenbo Xu, Zhi-Xiang Yu* and Jian Wang*
*College of Chemistry, Peking University, Beijing 100871; School of Medicine, Tsinghua University, Beijing 100084, China, Email: yuzxpku.edu.cn, wangjian2012tsinghua.edu.cn
J. Wu, W. Xu, Z.-X. Yu, J. Wang, J. Am. Chem. Soc., 2015, 137, 9489-9495.
DOI: 10.1021/jacs.5b06400 (free Supporting Information)
see article for more reactions
A ruthenium-catalyzed formal dehydrative [4 + 2] cycloaddition of enamides and alkynes enables a mild and economic construction of a broad range of highly substituted pyridines. The reaction tolerates many functional groups and offers excellent regioselectivities.
see article for more examples