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Synthesis of 2-Quinolinones through Palladium(II) Acetate Catalyzed Cyclization of N-(2-Formylaryl)alkynamides

Jianbo Zhang, Xiuling Han*, Xiyan Lu*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China, Email: xlhanmail.sioc.ac.cn, xylumail.sioc.ac.cn

J. Zhang, X. Han, X. Lu, Synlett, 2015, 26, 1744-1748.

DOI: 10.1055/s-0034-1380751

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Abstract

A Pd(OAc)2-catalyzed cyclization of N-(2-formyl­aryl)alkynamides provides an efficient and atom-economical synthesis of 2-quinolinone derivatives via oxypalladation of alkynes.


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Key Words

cascade reaction, cyclization, oxypalladation, palladium, 2-quinolones

ID: J60-Y2015