Nucleophilic Trifluoromethylation of N-Tosyl Aldimines
G. K. Surya Prakash*, Mihirbaran Mandal, George A. Olah
*Loker Hydrocarbon Research Institute and Department of Chemistry,
UniVersity of Southern California, Los Angeles, California 90089-1661, Email:
gprakashusc.edu
G. K. S. Prakash, M. Mandal, G. A. Olah, Synlett, 2001, 77-78.
DOI: 10.1055/s-0034-1380210
Abstract
TMSCF3 and tetrabutylammonium (triphenylsilyl) difluorosilicate (TBAT) were used for efficient nucleophilic trifluoromethylation of aromatic, aliphatic and α,β-unsaturated sulfonaldimines to yield the corresponding sulfonamide adducts in good to excellent yields.
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G. K. S. Prakash, R. Krishnamurti, G. A. Olah, J. Am. Chem. Soc., 1989, 111, 393-395.
Key Words
amines, drugs, imines, nucleophilic addition, trifluoromethylation, sulfonamides
ID: J60-Y2001