Organic Chemistry Portal



Metal-Free Direct Oxidation of Aldehydes to Esters Using TCCA

Silvia Gaspa, Andrea Porcheddu and Lidia De Luca*

*Dipartimento di Chimica e Farmacia, UniversitÓ degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy, Email:

S. Gaspa, A. Porcheddu, L. De Luca, Org. Lett., 2015, 17, 3666-3669.

DOI: 10.1021/acs.orglett.5b01579 (free Supporting Information)

see article for more reactions


In a mild and efficient oxidative esterification using TCCA as the oxidant, aromatic and aliphatic aldehydes are converted in situ into their corresponding acyl chlorides, which are then reacted with primary and secondary aliphatic, benzylic, allylic, and propargylic alcohols and phenols to give various esters in high yields.

see article for more examples

Key Words

oxidative esterification, TCCA

ID: J54-Y2015