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Highly Regioselective Indoline Synthesis under Nickel/Photoredox Dual Catalysis

Sarah Z. Tasker and Timothy F. Jamison*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email:

S. Z. Tasker, T. F. Jamison, J. Am. Chem. Soc., 2015, 137, 9531-9534.

DOI: 10.1021/jacs.5b05597 (free Supporting Information)

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In a nickel/photoredox catalyzed synthesis of indolines from iodoacetanilides and alkenes, very high regioselectivity for 3-substituted indoline products is obtained for both aliphatic and styrenyl olefins. This process demonstrates the utility of photoredox catalysts as controlled single electron transfer agents in multioxidation state nickel catalysis.

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ID: J48-Y2015