Organic Chemistry Portal



Divergent Synthesis of 2-Aminofurans via Palladium-Catalyzed Acetoxylative, Alkoxylative, and Hydroxylative Cycloisomerization of Homoallenyl Amides

Cungui Cheng, Shuiyou Liu and Gangguo Zhu*

*Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China, Email:

C. Cheng, S. Liu, G. Zhu, J. Org. Chem., 2015, 80, 7604-7612.

DOI: 10.1021/acs.joc.5b01182

see article for more reactions


Hypervalent iodine compounds enable Pd-catalyzed acetoxylative, alkoxylative, and hydroxylative cycloisomerizations of homoallenyl amides to give three different types of polysubstituted 2-aminofurans in promising yields at room temperature.

see article for more examples

Key Words

Furans, PIDA

ID: J42-Y2015