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Copper-Catalyzed Cross-Coupling Reaction of Allyl Boron Ester with 1°/2°/3°-Halogenated Alkanes

Guang-Zu Wang, Jian Jiang, Xiao-Song Bu, Jian-Jun Dai, Jun Xu, Yao Fu* and Hua-Jian Xu*

*University of Science and Technology of China, Hefei 230026; Hefei University of Technology, Hefei 230009, P. R. China, Email: fuyaoustc.edu.cn, hjxuhfut.edu.cn

G.-Z. Wang, J. Jiang, X.-S. Bu, J.-J. Dai, J. Xu, Y. Fu, H.-J. Xu, Org. Lett., 2015, 17, 3682-3685.

DOI: 10.1021/acs.orglett.5b01612



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Abstract

A Cu-catalyzed cross-coupling reaction of allyl boron ester with halogenated alkanes provides a mild and efficient method for the construction of saturated C(sp3)-C(sp3) bonds. This protocol works with nonactivated primary, secondary, and even tertiary halogenated alkanes under mild conditions.

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Key Words

allylation


ID: J54-Y2015