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Buchwald-Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst

Yin Zhang, Guy Lavigne and Vincent CÚsar*

*CNRS, LCC (laboratoire de Chimie de Coordination), 205 route de Narbonne, F-31077 Toulouse Cedex 4, France, Email:

Y. Zhang, G. Lavigne, V. CÚsar, J. Org. Chem., 2015, 80, 7666-7673.

DOI: 10.1021/acs.joc.5b01272


A cross-coupling of aryl tosylates with amines and anilines was achieved by using a Pd-NHC system based on the popular Pd-PEPPSI precatalyst. The NHC ligand incorporates two dimethylamino groups as backbone substituents for enhancing both the electronic and steric properties of the carbene.

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Key Words

Buchwald-Hartwig Coupling, Arylation

ID: J42-Y2015