Stereoselective Synthesis of 3-Carboxy-4,5-dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction
Jinbao Xiang, Hongxiang Xie, Zhuo Li, Qun Dang and Xu Bai*
*The School of Pharmaceutical Sciences and The College of
Chemistry, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, P. R.
China, Email: xbai
jlu.edu.cn
J. Yiang, H. Xie, Z. Li, Q. Dang, X. Bai, Org. Lett., 2015, 17, 3810-3813.
DOI: 10.1021/acs.orglett.5b01787
see article for more reactions
Abstract
An intramolecular iminium ion cyclization reaction of readily accessible Baylis-Hillman derivatives and aldehydes enables a synthesis of trans-4,5-disubstituted 3-carboxy-4,5-dihydropyrroles in good yield. These dihydropyrroles can easily be converted to pyrroles or pyrrolidines.
see article for more examples
Key Words
ID: J54-Y2015
