Organic Chemistry Portal



Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins

Fernando Fernández-Nieto, Josep Mas Roselló, Simone Lenoir, Simon Hardy and Jonathan Clayden*

*School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, U.K., Email:

F. Fernández-Nieto, J. M. Roselló, S. Lenoir, S. Hardy, J. Clayden, Org. Lett., 2015, 17, 3838-3841.

DOI: 10.1021/acs.orglett.5b01803 (free Supporting Information)

see article for more reactions


Palladium(II) trifluoroacetate catalyzes the C-arylation of N,N-disubstituted hydantoins by aryl iodides in good yield. The reaction is successful with various hydantoins and a range of electron-rich and electron-poor aryl iodides.

see article for more examples

Key Words


ID: J54-Y2015