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tert-Butyl Peroxybenzoate Mediated Selective and Mild N-Benzoylation of Ammonia/Amines under Catalyst- and Solvent-Free Conditions

Dilip Kumar T. Yadav, Bhalchandra M. Bhanage*

*Department of Chemistry, Institute of Chemical Technology, N.P. Marg, Matunga-400019, Mumbai, India, Email: bm.bhanageictmumbai.edu.in

D. K. T. Yadav, B. M. Bhanage, Synlett, 2015, 26, 1862-1866.

DOI: 10.1055/s-0034-1380811 (free Supporting Information)



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Abstract

The reaction of tert-butyl peroxybenzoate (TBPB) and ammonia/amines provides the corresponding primary, secondary, and tertiary amides under catalyst- and solvent-free conditions in excellent yields. TBPB is an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the presence of aromatic amines and hydroxyl groups.

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Key Words

tert-butyl peroxybenzoate, N-benzoylation, catalyst-free, solvent-free, amides


ID: J60-Y2015