Organic Chemistry Portal

Abstracts

Search:

tert-Butyl Peroxybenzoate Mediated Selective and Mild N-Benzoylation of Ammonia/Amines under Catalyst- and Solvent-Free Conditions

Dilip Kumar T. Yadav, Bhalchandra M. Bhanage*

*Department of Chemistry, Institute of Chemical Technology, N.P. Marg, Matunga-400019, Mumbai, India, Email: bm.bhanageictmumbai.edu.in

D. K. T. Yadav, B. M. Bhanage, Synlett, 2015, 26, 1862-1866.

DOI: 10.1055/s-0034-1380811



see article for more reactions

Abstract

The reaction of tert-butyl peroxybenzoate (TBPB) and ammonia/amines provides the corresponding primary, secondary, and tertiary amides under catalyst- and solvent-free conditions in excellent yields. TBPB is an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the presence of aromatic amines and hydroxyl groups.

see article for more examples



Key Words

tert-butyl peroxybenzoate, N-benzoylation, catalyst-free, solvent-free, amides


ID: J60-Y2015