tert-Butyl Peroxybenzoate Mediated Selective and Mild N-Benzoylation of Ammonia/Amines under Catalyst- and Solvent-Free Conditions
Dilip Kumar T. Yadav, Bhalchandra M. Bhanage*
*Department of Chemistry, Institute of Chemical Technology,
N.P. Marg, Matunga-400019, Mumbai, India, Email: bm.bhanage
ictmumbai.edu.in
D. K. T. Yadav, B. M. Bhanage, Synlett, 2015, 26, 1862-1866.
DOI: 10.1055/s-0034-1380811
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Abstract
The reaction of tert-butyl peroxybenzoate (TBPB) and ammonia/amines provides the corresponding primary, secondary, and tertiary amides under catalyst- and solvent-free conditions in excellent yields. TBPB is an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the presence of aromatic amines and hydroxyl groups.
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Key Words
tert-butyl peroxybenzoate, N-benzoylation, catalyst-free, solvent-free, amides
ID: J60-Y2015
