Ligand-Free Pd-Catalyzed Double Carbonylation of Aryl Iodides with Amines to α-Ketoamides under Atmospheric Pressure of Carbon Monoxide and at Room Temperature
Hongyan Du, Qing Ruan, Minghao Qi and Wei Han*
*School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China, Email: hanweinjnu.edu.cn
H. Du, Q. Ruan, M. Qi, W. Han, J. Org. Chem., 2015, 80, 7816-7823.
DOI: 10.1021/acs.joc.5b01249 (free Supporting Information)
A general Pd-catalyzed double carbonylation of aryl iodides with secondary or primary amines provides α-ketoamides in high yields with excellent chemoselectivities at atmospheric CO pressure. This transformation proceeds successfully even at room temperature and in the absence of any ligand and additive.
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