Organic Chemistry Portal

Abstracts

Search:

Ligand-Free Pd-Catalyzed Double Carbonylation of Aryl Iodides with Amines to α-Ketoamides under Atmospheric Pressure of Carbon Monoxide and at Room Temperature

Hongyan Du, Qing Ruan, Minghao Qi and Wei Han*

*School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China, Email: hanweinjnu.edu.cn

H. Du, Q. Ruan, M. Qi, W. Han, J. Org. Chem., 2015, 80, 7816-7823.

DOI: 10.1021/acs.joc.5b01249


Abstract

A general Pd-catalyzed double carbonylation of aryl iodides with secondary or primary amines provides α-ketoamides in high yields with excellent chemoselectivities at atmospheric CO pressure. This transformation proceeds successfully even at room temperature and in the absence of any ligand and additive.

see article for more examples


While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:

If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!


Key Words

carbonylation of arenes, aminocarbonylation, α-keto amides


ID: J42-Y2015