Organic Chemistry Portal



A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

Yuelu Zhu, Cheng Li, Jidong Zhang, Mengyao She, Wei Sun, Kerou Wan, Yaqi Wang, Bin Yin, Ping Liu and Jianli Li*

*Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education and College of Chemistry & Materials Science, Northwest University, Xi'an Shaanxi 710127, P. R. China, Email:

Y. Zhu, C. Li, J. Zhang, M. She, W. Sun, K. Wan, Y. Wang, B. Yin, P. Liu, J. Li, Org. Lett., 2015, 17, 3872-3875.

DOI: 10.1021/acs.orglett.5b01854

see article for more reactions


A convenient and efficient FeCl3/I2-catalyzed aerobic oxidative coupling of amidines and chalcones provides tetrasubstituted imidazoles in high regioselectivity and yields. The reaction offers good functional group tolerance, and mild reaction conditions.

see article for more examples

Key Words

imidazoles, oxygen

ID: J54-Y2015