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Asymmetric Synthesis of α-Amino Ketones by Brønsted Acid Catalysis

Wei Wen, Yu Zeng, Li-Yu Peng, Li-Na Fu and Qi-Xiang Guo*

*School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China, Email: qxguoswu.edu.cn

W. Wen, Y. Zeng, L.-Y. Peng, L.-N. Fu, Q.-X. Guo, Org. Lett., 2015, 17, 3922-3925.

DOI: 10.1021/acs.orglett.5b01972 (free Supporting Information)


Abstract

Brønsted acid catalysis enables highly efficient, regioselective, and enantioselective transfer hydrogenation of α-keto ketimines and reductive amination of diketones. A series of chiral α-amino ketones is prepared in high yields, excellent regioselectivities, and enantioselectivities.

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Key Words

amination, reduction, reductive amination, organocatalysis


ID: J54-Y2015