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Facile Access to Benzothiophenes through Metal-Free Iodine-Catalyzed Intermolecular Cyclization of Thiophenols and Alkynes

Kelu Yan, Daoshan Yang*, Mengqi Zhang, Wei Wei, Yao Liu, Laijin Tian, Hua Wang*

*School of Chemistry and Chemical Engineering, Qufu Normal Univesity, Jingxuan Road, Qufu 273165, Shandong, P. R. of China, Email:,

K. Yan, S. Yang, M. Zhang, W. Wei, Y. Liu, L. Tian, H. Wang, Synlett, 2015, 26, 1890-1894.

DOI: 10.1055/s-0034-1378841

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Iodine-catalyzed cascade reactions of substituted thiophenols with alkynes under metal- and solvent-free conditions enable the synthesis of benzothiophene derivatives in good yields. Such an efficient, economical, and green transformation should provide an attractive approach to various benzothiophenes.

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Key Words

iodine-catalyzed, metal-free, benzothiophenes, thiophenols, alkynes, DTBP, green chemistry

ID: J60-Y2015