Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates
Brett R. Ambler, Lingui Zhu and Ryan A. Altman*
*Department of Medicinal Chemistry, The University of Kansas,
Lawrence, Kansas 66045, United States, Email: raaltman
ku.edu
B. R. Ambler, L. Zhu, R. A. Altman, J. Org. Chem., 2015, 80, 8449-8457.
DOI: 10.1021/acs.joc.5b01343
Abstract
Trifluoroethylarenes can be directly accessed via nucleophilic trifluoromethylation of benzylic electrophiles, but current catalytic methods fail to transform electron-deficient substrates and heterocycles. A Cu-catalyzed decarboxylative trifluoromethylation of benzylic bromodifluoroacetates effectively provides a wide range of trifluoroethylarenes.
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Key Words
ID: J42-Y2015
