Copper-Catalyzed Alkenylation of Alcohols with β-Nitrostyrenes via a Radical Addition-Elimination Process
Sheng-rong Guo, Yan-qin Yuan*
*Department of Chemistry, Lishui University, Lishui, 323000, P. R. of China, Email: yuanyq5474lsu.edu.cn
S.-r. Guo, Y.-q. Yuan, Synlett, 2015, 26, 1961-1968.
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The use of DTBP as radical initiator and a copper salt as promoter enables the preparation of allylic alcohol, benzyl, and alkane derivatives via a radical mechanism. The C(sp3)-H bond in various alcohols, toluene derivatives, and alkanes were successfully alkenylated with β-nitrostyrenes to yield the desired products in good yields.
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(E)-β-nitrostyrenes, alkenylation, allylic alcohols, free-radical, C(sp3)-H bonds, DTBP