Copper-Catalyzed Alkenylation of Alcohols with β-Nitrostyrenes via a Radical Addition-Elimination Process

Sheng-rong Guo, Yan-qin Yuan*

*Department of Chemistry, Lishui University, Lishui, 323000, P. R. of China, Email: yuanyq5474lsu.edu.cn

S.-r. Guo, Y.-q. Yuan, Synlett, 2015, 26, 1961-1968.

DOI: 10.1055/s-0034-1380445

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Abstract

The use of DTBP as radical initiator and a copper salt as promoter enables the preparation of allylic alcohol, benzyl, and alkane derivatives via a radical mechanism. The C(sp³)-H bond in various alcohols, toluene derivatives, and alkanes were successfully alkenylated with β-nitrostyrenes to yield the desired products in good yields.

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Key Words

(E)-β-nitrostyrenes, alkenylation, allylic alcohols, free-radical, C(sp³)-H bonds, DTBP

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ID: J60-Y2015