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Copper-Catalyzed Ligand-Free Amidation of Benzylic Hydrocarbons and Inactive Aliphatic Alkanes

Hui-Ting Zeng and Jing-Mei Huang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China, Email: chehjmscut.edu.cn

H.-T. Zeng, J.-M. Huang, Org. Lett., 2015, 17, 4276-4279.

DOI: 10.1021/acs.orglett.5b02063


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Abstract

An efficient copper-catalyzed amidation of benzylic hydrocarbons and inactive aliphatic alkanes with simple amides proceeded smoothly without any ligand. A wide range of N-alkylated aromatic and aliphatic amides, sulfonamides, and imides were synthesized in good yields.

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Key Words

amides, DTBP


ID: J54-Y2015