Copper-Catalyzed Ligand-Free Amidation of Benzylic Hydrocarbons and Inactive Aliphatic Alkanes
Hui-Ting Zeng and Jing-Mei Huang*
*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China, Email: chehjmscut.edu.cn
H.-T. Zeng, J.-M. Huang, Org. Lett., 2015, 17, 4276-4279.
DOI: 10.1021/acs.orglett.5b02063 (free Supporting Information)
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An efficient copper-catalyzed amidation of benzylic hydrocarbons and inactive aliphatic alkanes with simple amides proceeded smoothly without any ligand. A wide range of N-alkylated aromatic and aliphatic amides, sulfonamides, and imides were synthesized in good yields.
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