Copper(I)-Catalyzed Radical Addition of Acetophenones to Alkynes in Furan Synthesis

Srimanta Manna and Andrey P. Antonchick*

*Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany, Email: andrey.antonchickmpi-dortmund.mpg.de

S. Manna, A. P. Antonchick, Org. Lett., 2015, 17, 4300-4303.

DOI: 10.1021/acs.orglett.5b02114

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Abstract

Copper(I) salts catalyze a synthesis of multisubstituted furans from readily available acetophenones and electron-deficient alkynes via direct C(sp³)-H bond functionalization under radical reaction conditions in the presence of di-tert-butyl peroxide as an external oxidant. This method offers an efficient access to biologically important scaffolds from simple compounds.

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Key Words

Furans, DTBP

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ID: J54-Y2015