A Bio-Inspired, Catalytic E → Z Isomerization of Activated Olefins
Jan B. Metternich and Ryan Gilmour*
*Institute for Organic Chemistry, Westfälische
Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany, Email:
ryan.gilmour
uni-muenster.de
J. B. Metternich, R. Gilmour, J. Am. Chem. Soc., 2015, 137, 11254-11257.
DOI: 10.1021/jacs.5b07136
see article for more reactions
Abstract
A riboflavin-mediated highly (Z)-selective and operationally simple, catalytic isomerization has been applied to a variety of enone-derived substrates. The reaction can also be used for the synthesis of the medically relevant 4-substituted coumarin scaffold.
see article for more examples
Key Words
isomerizations, unsaturated esters
ID: J48-Y2015
