A Bio-Inspired, Catalytic E → Z Isomerization of Activated Olefins
Jan B. Metternich and Ryan Gilmour*
*Institute for Organic Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany, Email: ryan.gilmouruni-muenster.de
J. B. Metternich, R. Gilmour, J. Am. Chem. Soc., 2015, 137, 11254-11257.
DOI: 10.1021/jacs.5b07136 (free Supporting Information)
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A riboflavin-mediated highly (Z)-selective and operationally simple, catalytic isomerization has been applied to a variety of enone-derived substrates. The reaction can also be used for the synthesis of the medically relevant 4-substituted coumarin scaffold.
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