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Cu-Catalyzed Three-Component Cascade Annulation Reaction: An Entry to Functionalized Pyridines

Huanfeng Jiang*, Jidan Yang, Xiaodong Tang, Jianxiao Li and Wanqing Wu

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China, Email:

H. Jiang, J. Yang, X. Tang, J. Li, W. Wu, J. Org. Chem., 2015, 80, 8763-8771.

DOI: 10.1021/acs.joc.5b01621 (free Supporting Information)


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A concise copper-catalyzed N-O bond cleavage/C-C/C-N bond formation procedure enables the synthesis of multisubstituted pyridines from various oxime acetates, activated methylene compounds, and a wide range of aldehydes. This method features inexpensive catalysts, no need for extra oxidant, and high step-economy.

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Key Words

pyridines, multicomponent reactions

ID: J42-Y2015