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An Improved Synthesis of 2-Aryl- and 2-Alkenyl-1,3,4-oxadiazoles by Using Copper(II) Oxide Nanoparticles as a Catalyst

N. Salva Reddy, P. Raghavendar Reddy, Biswanath Das*

*Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India, Email:

N. S. Reddy, P. R. Reddy, B. Das, Synthesis, 2015, 47, 2831-2838.

DOI: 10.1055/s-0034-1380923 (free Supporting Information)

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2-Aryl- and 2-alkenyl-1,3,4-oxadiazoles were efficiently synthesized in high yields by treatment of 1,3,4-oxadiazoles with aryl or alkenyl halides, respectively, in the presence of copper(II) oxide nanoparticles as reusable catalyst.

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Key Words

1,3,4-oxadiazoles, copper, catalysis, nanoparticles, arylations, alkenylations

ID: J66-Y2015