Pd-Catalyzed Stereoselective Carboperfluoroalkylation of Alkynes
Zhaodong Li, Andrés García-Domínguez and Cristina Nevado*
*Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland, Email: cristina.nevadochem.uzh.ch
Z. Li, A. García-Domínguez, C. Nevado, J. Am. Chem. Soc., 2015, 137, 11610-11613.
DOI: 10.1021/jacs.5b07432 (free Supporting Information)
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An operationally simple Pd-catalyzed three component reaction involving terminal alkynes, boronic acids, and perfluoroalkyl iodides gives trisubstituted perfluoroalkenes in a highly regio- and stereocontrolled manner by simultaneous additions across the triple bond in a radical-mediated process. The reaction is broad in scope and tolerates many functional groups.
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