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Copper-Catalyzed Oxidative Coupling-Annulation: One-Pot Synthesis of Indolizines from 2-Alkylazaarenes with Alkenes

Jing-ling Liu, Ying Liang*, Heng-shan Wang, Ying-ming Pan*

*Guilin University of Electronic Technolegy, Guilin, 541004; Guangxi Normal University, Guilin, 541004, P. R. of China, Email: yinglaliyun.com, panym2013hotmail.com

J.-l. Liu, Y.-L. Liang, H.-s. Wang, Y.-m. Pan, Synlett, 2015, 26, 2024-2028.

DOI: 10.1055/s-0034-1378785


Abstract

A copper-catalyzed highly selective oxidative coupling-annulation of 2-alkylazaarenes with terminal alkenes provides a simple, efficient, and atom-economic synthesis of indolizines in good yields.

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Key Words

indolizines, alkenes, 2-alkylazaarenes, oxidative coupling, oxygen, annulation


ID: J60-Y2015