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Aldehyde-Promoted One-Pot Regiospecific Synthesis of Acrylamides Using an in Situ Generated Molybdenum Tetracarbonyl Amine [Mo(CO)4(amine)2] Complex

Atulya Nagarsenkar, Santosh Kumar Prajapti, Sravanthi Devi Guggilapu and Bathini Nagendra Babu*

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana India 500037, Email: bathininiperhyd.ac.in

A. Nagarsenkar, S. K. Prajapti, S. D. Guggilapu, B. N. Babu, Org. Lett., 2015, 17, 4592-4595.

DOI: 10.1021/acs.orglett.5b02231 (free Supporting Information)


Abstract

The use of Mo(CO)6 and an amine enables a regiospecific, Pd-free aminocarbonylation of various terminal alkynes. The Mo(CO)6-amine system played a dual role as complexing agent and as CO donor.

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Key Words

α,β-unsaturated amides, aminocarbonylation, multicomponent reactions


ID: J54-Y2015