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Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: A Method for the Synthesis of Ketals and Ketones

Xiaofeng Ma, Xiya Luo, Simon Dochain, Charlotte Mathot and István E. Markň*

*Laboratory of Organic and Medicinal Chemistry, Université Catholique de Louvain, Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium, Email:

X. Ma, Y. Luo, S. Dochain, C. Mathot, I. E. Marko, Org. Lett., 2015, 17, 4690-4693.

DOI: 10.1021/acs.orglett.5b02084

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An electrochemical oxidative decarboxylation of wide range of disubstituted malonic acids leads to dimethoxy ketals in very good yields in the presence of NH3. Treatment of the crude reaction mixture after electrolysis with 1 M aq HCl enables the synthesis of ketones in a single vessel operation.

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Key Words

ketones, electrochemistry

ID: J54-Y2015