Organic Chemistry Portal



Silver-Catalyzed Decarboxylative Azidation of Aliphatic Carboxylic Acids

Yuchao Zhu, Xinyao Li, Xiaoyang Wang, Xiaoqiang Huang, Tao Shen, Yiqun Zhang, Xiang Sun, Miancheng Zou, Song Song* and Ning Jiao*

*State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China, Email:,

Y. Zhu, X. Liu, X. Wang, X. Huang, T. Shen, Y. Zhang, X. Sun, M. Zou, S. Song, N. Jiao, Org. Lett., 2015, 17, 4702-4705.

DOI: 10.1021/acs.orglett.5b02155

see article for more reactions


In a catalytic decarboxylative nitrogenation, a series of tertiary, secondary, and primary organoazides were prepared from easily available aliphatic carboxylic acids by using K2S2O8 as the oxidant and PhSO2N3 as the nitrogen source via an alkyl radical process.

see article for more examples

Key Words

alkyl azides, potassium peroxydisulfate

ID: J54-Y2015