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A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes

K. A. Aravinda Kumar, Vunnam Venkateswarlu, Ram A. Vishwakarma, Sanghapal D. Sawant*

*Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180 001, India, Email:

K. A. A. Kumar, V. Venkateswarlu, R. A. Vishwakarma, S. D. Sawant, Synthesis, 2015, 47, 3161-3168.

DOI: 10.1055/s-0034-1381026

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A mixture of Oxone and trifluoroacetic acid enables a simple and mild metal-free oxidation of various ketones or arylalkynes to the corresponding carboxylic acids in excellent yields.

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Key Words

ketones, alkynes, oxidation, carboxylic acids, Oxone

ID: J66-Y2015