A Metal-Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes
K. A. Aravinda Kumar, Vunnam Venkateswarlu, Ram A. Vishwakarma, Sanghapal D. Sawant*
*Medicinal Chemistry Division, CSIR-Indian Institute of
Integrative Medicine, Canal Road, Jammu-180 001, India, Email: sdsawant
iiim.res.in
K. A. A. Kumar, V. Venkateswarlu, R. A. Vishwakarma, S. D. Sawant, Synthesis, 2015, 47, 3161-3168.
DOI: 10.1055/s-0034-1381026
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Abstract
A mixture of Oxone and trifluoroacetic acid enables a simple and mild metal-free oxidation of various ketones or arylalkynes to the corresponding carboxylic acids in excellent yields.
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Key Words
ketones, alkynes, oxidation, carboxylic acids, Oxone
ID: J66-Y2015
