Confined Acid-Catalyzed Asymmetric Carbonyl-Ene Cyclization
Luping Liu, Markus Leutzsch, Yiying Zheng, M. Wasim Alachraf, Walter Thiel and Benjamin List*
*Max-Planck-Institut für Kohlenforschung, Kaiser
Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Email: list
kofo.mpg.de
L. Liu, M. Leutzsch, Y. Zheng, M. W. Alachraf, W. Thiel, B. List, J. Am. Chem. Soc., 2015, 137, 13268-13271.
DOI: 10.1021/jacs.5b09484
see article for more reactions
Abstract
Using a confined imidodiphosphate catalyst, a highly enantioselective intramolecular carbonyl-ene reaction of olefinic aldehydes delivers diverse trans-3,4-disubstituted carbo- and heterocyclic five-membered rings in high yields and with good to excellent diastereo- and enantioselectivities.
see article for more examples
Key Words
Pyrrolidines, Alder-Ene Reaction, Organocatalysis
ID: J48-Y2015
