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Copper-Catalyzed Electrophilic Amination of Heteroarenes via C-H Alumination

Hongju Yoon and Yunmi Lee*

*Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea, Email:

H. Yoon, Y. Lee, J. Org. Chem., 2015, 80, 10244-10251.

DOI: 10.1021/acs.joc.5b01863

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CuCl catalyzes a highly efficient electrophilic amination reaction of readily available heteroarenes with O-benzoyl hydroxylamines via a one-pot C-H alumination to afford various heteroaryl amines in very good yields. The reaction can be performed in a single vessel on gram scales.

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Key Words

arylation, benzofurans, benzothiophenes, indoles

ID: J42-Y2015