Copper-Catalyzed Carboxylation of Alkenylzirconocenes with Carbon Dioxide Leading to α,β-Unsaturated Carboxylic Acids
Sheng Wang, Peng Shao, Chao Chen and Chanjuan Xi*
*Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: cjxitsinghua.edu.cn
S. Wang, P. Shao, C. Chen, C. Xi, Org. Lett., 2015, 17, 5112-5115.
DOI: 10.1021/acs.orglett.5b02619 (free Supporting Information)
see article for more reactions
Various alkenylzirconocenes, prepared in situ by a carbozirconation of alkynes, were efficiently carboxylated in the presence of CO2 using (IMes)CuCl as catalyst at room temperature to provide the corresponding α,β-unsaturated carboxylic acids in good yields.
see article for more examples