Copper-Catalyzed Carboxylation of Alkenylzirconocenes with Carbon Dioxide Leading to α,β-Unsaturated Carboxylic Acids

Sheng Wang, Peng Shao, Chao Chen and Chanjuan Xi*

*Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: cjxitsinghua.edu.cn

S. Wang, P. Shao, C. Chen, C. Xi, Org. Lett., 2015, 17, 5112-5115.

DOI: 10.1021/acs.orglett.5b02619

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Abstract

Various alkenylzirconocenes, prepared in situ by a carbozirconation of alkynes, were efficiently carboxylated in the presence of CO₂ using (IMes)CuCl as catalyst at room temperature to provide the corresponding α,β-unsaturated carboxylic acids in good yields.

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Key Words

α,β-unsaturated carboxylic acids

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ID: J54-Y2015