Organic Chemistry Portal



Palladium-Catalyzed Carbonylative Annulation Reactions Using Aryl Formate as a CO Source: Synthesis of 2-Substituted Indene-1,3(2H)-dione Derivatives

Ying Zhang, Jing-Lei Chen, Zhen-Bang Chen, Yong-Ming Zhu* and Shun-Jun Ji*

*Soochow University, Suzhou 215123, China, Email:,

Y. Zhang, J.-L. Chen, Z.-B. Chen, Y.-M. Zhu, S.-J. Ji, J. Org. Chem., 2015, 80, 10643-10650.

DOI: 10.1021/acs.joc.5b01758 (free Supporting Information)



A palladium-catalyzed intramolecular carbonylative annulation with phenyl formate as a CO source enables an efficient synthesis of 2-substituted indene-1,3(2H)-diones from stable and readily available 1-(2-halophenyl)-1,3-diones using K3PO4 as a base and DMSO as a solvent at 95 C. The reaction offers a broad substrate scope with good to excellent yields.

see article for more examples

Key Words

indanones, aryl ketones

ID: J42-Y2015