Synthesis of a-Alkylated Ketones via Tandem Acceptorless Dehydrogenation/a-Alkylation from Secondary and Primary Alcohols Catalyzed by Metal-Ligand Bifunctional Iridium Complex [Cp*Ir(2,2′-bpyO)(H₂O)]

Rongzhou Wang, Juan Ma and Feng Li*

*School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, People's Republic of China, Email: fenglinjust.edu.cn

R. Wang, J. Ma, F. Li, J. Org. Chem., 2015, 80, 10769-10776.

DOI: 10.1021/acs.joc.5b01975

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Abstract

In the presence of metal-ligand bifunctional iridium complex [Cp*Ir(2,2′-bpyO)(H₂O)], a tandem acceptorless dehydrogenation/α-alkylation of secondary and primary alcohols provides α-alkylated ketones in high yields. This protocol offers complete selectivity for α-alkylated ketones and environmentally benign conditions.

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Key Words

α-alkylation

ID: J42-Y2015

Synthesis of a-Alkylated Ketones via Tandem Acceptorless Dehydrogenation/a-Alkylation from Secondary and Primary Alcohols Catalyzed by Metal-Ligand Bifunctional Iridium Complex [Cp*Ir(2,2′-bpyO)(H2O)]

Rongzhou Wang, Juan Ma and Feng Li*

Synthesis of a-Alkylated Ketones via Tandem Acceptorless Dehydrogenation/a-Alkylation from Secondary and Primary Alcohols Catalyzed by Metal-Ligand Bifunctional Iridium Complex [Cp*Ir(2,2′-bpyO)(H₂O)]