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Rhodium(II)-Catalyzed Formal [3 + 2] Cycloaddition of N-Sulfonyl-1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted 3-Aminopyrroles

Xiaoqiang Lei, Longbo Li, Yu-Peng He* and Yefeng Tang*

*Liaoning Shihua University, Dandong Lu West 1, Fushun 113001; Tsinghua University, Beijing 100084, China, Email:,

X. Lei, L. Li, Y.-P. He, Y. Tang, Org. Lett., 2015, 17, 5224-5227.

DOI: 10.1021/acs.orglett.5b02570 (free Supporting Information)

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A rhodium(II)-catalyzed formal [3 + 2] cycloaddition of N-sulfonyl-1,2,3-triazoles with isoxazoles provides polysubstituted 3-aminopyrrole derivatives. An operationally simple one-pot synthesis of the titled compounds from terminal alkynes, tosyl azide, and isoxazoles was also developed.

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ID: J54-Y2015