Rhodium(II)-Catalyzed Formal [3 + 2] Cycloaddition of N-Sulfonyl-1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted 3-Aminopyrroles
Xiaoqiang Lei, Longbo Li, Yu-Peng He* and Yefeng Tang*
*Liaoning Shihua University, Dandong Lu West 1, Fushun
113001; Tsinghua University, Beijing 100084, China, Email: yupeng.he
aliyun.com,
yefengtangtsinghua.edu.cn
X. Lei, L. Li, Y.-P. He, Y. Tang, Org. Lett., 2015, 17, 5224-5227.
DOI: 10.1021/acs.orglett.5b02570
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Abstract
A rhodium(II)-catalyzed formal [3 + 2] cycloaddition of N-sulfonyl-1,2,3-triazoles with isoxazoles provides polysubstituted 3-aminopyrrole derivatives. An operationally simple one-pot synthesis of the titled compounds from terminal alkynes, tosyl azide, and isoxazoles was also developed.
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Key Words
ID: J54-Y2015
