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Copper(II) Triflate Catalyzed Synthesis of 2,4-Disubstituted Oxazoles from α-Diazoketones

M. Ramana Reddy, G. Niranjan Reddy, Umer Mehmood, Ibnelwaleed A. Hussein, S. U. Rahman, Khalil Harrabi, Basireddy V. Subba Reddy*

*Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: basireddyiict.res.in

M. R. Reddy, G. N. Reddy, U. Mehmood, I. A. Hussein, S. U. Rahman, K. Harrabi, B. V. S. Reddy, Synthesis, 2015, 47, 3315-3320.

DOI: 10.1055/s-0034-1378860 (free Supporting Information)



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Abstract

Copper(II) triflate as catalyst enables a coupling of α-diazoketones with amides to provide 2,4-disubstituted oxazoles. The synthetic versatility of this approach is exemplified in the synthesis of an analogue of balsoxin.

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Key Words

α-diazoketones, amides, copper(II) triflate, oxazoles


ID: J66-Y2015