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Direct Alkylation of Amines with Alcohols Catalyzed by Base

Qiang-Qiang Li, Zu-Feng Xiao, Chuan-Zhi Yao, Hong-Xing Zheng and Yan-Biao Kang*

*Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China, Email: ybkangustc.edu.cn

Q.-Q. Li, Z.-F. Xiao, C.-Z. Yao, H.-X. Zheng, Y.-B. Kang, Org. Lett., 2015, 17, 5328-5331.

DOI: 10.1021/acs.orglett.5b02685 (free Supporting Information)


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Abstract

A base-catalyzed/promoted transition-metal-free direct alkylation of amines with either aromatic or aliphatic alcohols provides the desired amines in good yields.

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Key Words

sulfonamides, benzyl amines, aryl amines


ID: J54-Y2015