Direct Alkylation of Amines with Alcohols Catalyzed by Base
Qiang-Qiang Li, Zu-Feng Xiao, Chuan-Zhi Yao, Hong-Xing Zheng and Yan-Biao Kang*
*Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China, Email: ybkangustc.edu.cn
Q.-Q. Li, Z.-F. Xiao, C.-Z. Yao, H.-X. Zheng, Y.-B. Kang, Org. Lett., 2015, 17, 5328-5331.
DOI: 10.1021/acs.orglett.5b02685 (free Supporting Information)
see article for more reactions
A base-catalyzed/promoted transition-metal-free direct alkylation of amines with either aromatic or aliphatic alcohols provides the desired amines in good yields.
see article for more examples