Organic Chemistry Portal



Direct Alkylation of Amines with Alcohols Catalyzed by Base

Qiang-Qiang Li, Zu-Feng Xiao, Chuan-Zhi Yao, Hong-Xing Zheng and Yan-Biao Kang*

*Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China, Email:

Q.-Q. Li, Z.-F. Xiao, C.-Z. Yao, H.-X. Zheng, Y.-B. Kang, Org. Lett., 2015, 17, 5328-5331.

DOI: 10.1021/acs.orglett.5b02685

see article for more reactions


A base-catalyzed/promoted transition-metal-free direct alkylation of amines with either aromatic or aliphatic alcohols provides the desired amines in good yields.

see article for more examples

Key Words

sulfonamides, benzyl amines, aryl amines

ID: J54-Y2015