Organic Chemistry Portal



Polysubstituted 2-Aminopyrrole Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer from Vinyl Azide to Ynamide: Reaction Scope and Mechanistic Insights

Yufeng Wu, Lei Zhu, Yinghua Yu, Xuesong Luo and Xueliang Huang*

*College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350108, P. R. China, Email:

Y. Wu, L. Zhu, Y. Yu, X. Luo, X. Huang, J. Org. Chem., 2015, 80, 11407-11416.

DOI: 10.1021/acs.joc.5b02057 (free Supporting Information)

see article for more reactions


A gold-catalyzed intermolecular reaction of vinyl azides and ynamides enables an efficient and mild approach to multisubstituted 2-aminopyrroles in very good yields.

see article for more examples

Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles

L. Zhu, Y. Yu, Z. Mao, X. Huang, Org. Lett., 2015, 17, 30-33.

Key Words


ID: J42-Y2015