Polysubstituted 2-Aminopyrrole Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer from Vinyl Azide to Ynamide: Reaction Scope and Mechanistic Insights
Yufeng Wu, Lei Zhu, Yinghua Yu, Xuesong Luo and Xueliang Huang*
*College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350108, P. R. China, Email: huangxlfjirsm.ac.cn
Y. Wu, L. Zhu, Y. Yu, X. Luo, X. Huang, J. Org. Chem., 2015, 80, 11407-11416.
DOI: 10.1021/acs.joc.5b02057
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Abstract
A gold-catalyzed intermolecular reaction of vinyl azides and ynamides enables an efficient and mild approach to multisubstituted 2-aminopyrroles in very good yields.
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L. Zhu, Y. Yu, Z. Mao, X. Huang, Org. Lett., 2015, 17, 30-33.
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ID: J42-Y2015