NaI-Mediated Acetamidosulphenylation of Alkenes with Nitriles as the Nucleophiles: A Direct Access to Acetamidosulfides
Yang Zheng, Yue He, Guangwei Rong, Xiaolu Zhang, Yuecheng Weng, Kuiyong Dong, Xinfang Xu* and Jincheng Mao*
*Key Laboratory of Organic Synthesis of Jiangsu Province,
College of Chemistry, Chemical Engineering and Materials Science, Soochow
University, Suzhou, 215123, China, Email: xinfangxu
suda.edu.cn,
jcmaoswpu.edu.cn
Y. Zheng, Y. He, G. Rong, X. Zhang, Y. Wang, K. Dong, X. Xu, J. Mao, Org. Lett., 2015, 17, 5444-5447.
DOI: 10.1021/acs.orglett.5b02752
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Abstract
A transition-metal-free, direct, and efficient acetamidosulphenylation reaction of alkenes using nitriles as the nucleophiles offers a broad substrate scope and high regioselectivity and provides straightforward access to acetamidosulfide derivatives in good yields via a radical process.
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Key Words
sulfides, Ritter reaction, ammonium peroxydisulfate
ID: J54-Y2015
