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An Efficient Method for the Synthesis of 2-Methylallyl Alkenes by Cross-Coupling Reactions

Clemence Tabélé, Christophe Curti, Nicolas Primas, Youssef Kabri, Vincent Remusat, Patrice Vanelle*

*Aix-Marseille Université, CNRS, ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 27 Boulevard Jean Moulin - CS30064, 13385 Marseille Cedex 05, France, Email:

C. Tabélé, C. Curti, N. Primas, Y. Kabri, V. Remusat, P. Vanelle, Synthesis, 2015, 47, 3339-3346.

DOI: 10.1055/s-0034-1381034 (free Supporting Information)

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A protocol with small amounts of palladium and ligand, without any additive solvent and under microwave heating enables cross-coupling reactions between 2-methyl-2-propen-1-ol and various boronic acids to yield aromatic 2-methylallyl derivatives.

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Key Words

palladium, cross-coupling reactions, methylallyl alkenes, boronic acids, allyl alcohols, microwave synthesis

ID: J66-Y2015