An Efficient Method for the Synthesis of 2-Methylallyl Alkenes by Cross-Coupling Reactions
Clemence Tabélé, Christophe Curti, Nicolas Primas, Youssef Kabri, Vincent Remusat, Patrice Vanelle*
*Aix-Marseille Université, CNRS, ICR, UMR 7273, Laboratoire
de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 27 Boulevard Jean Moulin -
CS30064, 13385 Marseille Cedex 05, France, Email: patrice.vanelle
univ-amu.fr
C. Tabélé, C. Curti, N. Primas, Y. Kabri, V. Remusat, P. Vanelle, Synthesis, 2015, 47, 3339-3346.
DOI: 10.1055/s-0034-1381034
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Abstract
A protocol with small amounts of palladium and ligand, without any additive solvent and under microwave heating enables cross-coupling reactions between 2-methyl-2-propen-1-ol and various boronic acids to yield aromatic 2-methylallyl derivatives.
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Key Words
palladium, cross-coupling reactions, methylallyl alkenes, boronic acids, allyl alcohols, microwave synthesis
ID: J66-Y2015
