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Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Hashim F. Motiwala, Rakesh H. Vekariya and Jeffrey Aubé*

*Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States, Email:

H. F. Motiwala, R. H. Vekariya, J. Aubé, Org. Lett., 2015, 17, 5484-5487.

DOI: 10.1021/acs.orglett.5b02851

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1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation of a broad range of arylalkyl acid chlorides without additional catalysts or reagents. This reaction is operationally trivial.

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Key Words

Friedel-Crafts Acylation, tetralones

ID: J54-Y2015