Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol
Hashim F. Motiwala, Rakesh H. Vekariya and Jeffrey Aubé*
*Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States, Email: jaubeunc.edu
H. F. Motiwala, R. H. Vekariya, J. Aubé, Org. Lett., 2015, 17, 5484-5487.
DOI: 10.1021/acs.orglett.5b02851 (free Supporting Information)
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1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation of a broad range of arylalkyl acid chlorides without additional catalysts or reagents. This reaction is operationally trivial.
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