C-N Coupling of Amides with Alcohols Catalyzed by N-Heterocyclic Carbene-Phosphine Iridium Complexes
Sutthichat Kerdphon, Xu Quan, Vijay Singh Parihar and Pher G. Andersson*
*Department of Organic Chemistry, Stockholm University,
S-10691, Stockholm, Sweden, Email: phera
organ.su.se
S. Kerdphon, X. Quan, V. S. Parihar, P. G. Andersson, J. Org. Chem., 2015, 80, 11529-11537.
DOI: 10.1021/acs.joc.5b01324
Abstract
N-Heterocyclic carbene-phosphine iridium complexes (NHC-Ir) are highly reactive catalysts for N-monoalkylation of amides with alcohols via hydrogen transfer. The reaction gave products in high isolated yields for a wide range of substrates with low catalyst loading and in short reaction times.
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Key Words
ID: J42-Y2015
