Organic Chemistry Portal



C-N Coupling of Amides with Alcohols Catalyzed by N-Heterocyclic Carbene-Phosphine Iridium Complexes

Sutthichat Kerdphon, Xu Quan, Vijay Singh Parihar and Pher G. Andersson*

*Department of Organic Chemistry, Stockholm University, S-10691, Stockholm, Sweden, Email:

S. Kerdphon, X. Quan, V. S. Parihar, P. G. Andersson, J. Org. Chem., 2015, 80, 11529-11537.

DOI: 10.1021/acs.joc.5b01324


N-Heterocyclic carbene-phosphine iridium complexes (NHC-Ir) are highly reactive catalysts for N-monoalkylation of amides with alcohols via hydrogen transfer. The reaction gave products in high isolated yields for a wide range of substrates with low catalyst loading and in short reaction times.

see article for more examples

Key Words

amides, benzylamines

ID: J42-Y2015