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A Single-Reagent-Driven Multistep One-Pot Preparation of Thiazolines and 1,3-Thiazines from Aldoximes, Nitriles, and Carboxylic Acids

Shubhankar Bhattacharyya, Uma Pathak*

*Synthetic Chemistry Division, Defence R & D Establishment, Jhansi Road, Gwalior 474002, India, Email: sc_drderediffmail.com

S. Battacharyya, U. Pathak, Synthesis, 2015, 47, 3553-3560.

DOI: 10.1055/s-0035-1560459 (free Supporting Information)


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Abstract

N-(ω-Bromoalkyl)dichlorothiophosphoramidates enable a single-reagent-driven multistep preparation of a wide range of 2-substituted thiazolines and 1,3-thiazines from aldoximes, nitriles, or carboxylic acids.

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Key Words

heterocycles, sulfur, tandem reaction, green chemistry, cyclization, thiazolines


ID: J66-Y2015