Aerobic Oxidative Conversion of Aromatic Aldehydes to Nitriles Using a Nitroxyl/NOx Catalyst System

Ji-Hyun Noh and Jinho Kim*

*Department of Chemistry and Research Institute of Natural Sciences, Incheon National University, Incheon 22012, Republic of Korea, Email: jinhoinu.ac.kr

J.-H. Noh, J. Kim, J. Org. Chem., 2015, 80, 11624-11628.

DOI: 10.1021/acs.joc.5b02333

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Abstract

In the presence of a catalytic amount of 4-AcNH-TEMPO, NaNO₂, and HNO₃, benzaldehydes underwent condensation with NH₄OAc and a subsequent aerobic oxidation to produce nitriles selectively under O₂. Aerobic oxidative conversion of a primary alcohol is also achieved.

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Key Words

nitriles, oxygen, TEMPO

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ID: J42-Y2015