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Synergistic Acid-Promoted Synthesis of Highly Substituted Butenolides via the Annulation of Keto Acids and Tertiary Alcohols

Wenbin Mao and Chen Zhu*

*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People's Republic of China, Email:

W. Mao, C. Zhu, Org. Lett., 2015, 17, 5710-5713.

DOI: 10.1021/acs.orglett.5b03026

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A combination of Lewis and Brønsted acids enables an efficient and practical approach to highly substituted butenolides via the annulation of keto acids and tertiary alcohols. Various highly substituted butenolides are readily produced in synthetically useful yields.

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ID: J54-Y2015