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A Catalyst-Free Synthesis of Phosphinic Amides Using O-Benzoylhydroxylamines

Rui Zhu, Chongqing Pan and Zhenhua Gu*

*Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China, Email: zhguustc.edu.cn

R. Zhu, C. Pan, Z. Gu, Org. Lett., 2015, 17, 5862-5865.

DOI: 10.1021/acs.orglett.5b03056 (free Supporting Information)


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Abstract

Simply heating secondary phosphine oxides and O-benzoylhydroxylamines in the presence of K2CO3 gives phosphinic amides in moderate to excellent yields under air. This method provides a practical and catalyst-free method for the synthesis of various synthetically valuable phosphinic amides.

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Key Words

phosphinic amides


ID: J54-Y2015