Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates
Wai Chung Fu, Chau Ming So and Fuk Yee Kwong*
*State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, Email: fuk-yee.kwongpolyu.edu.hk
W. C. Fu, C. M. So, F. Y. Kwong, Org. Lett., 2015, 17, 5906-5909.
DOI: 10.1021/acs.orglett.5b03104 (free Supporting Information)
A palladium-catalyzed phosphorylation of aryl mesylates and tosylates exhibits excellent functional group compatibility - including free amino, keto, ester, and amido groups. The mesylated derivatives of biologically active compounds such as 17β-estradiol and 6-hydroxyflavone are applicable substrates too.
see article for more examples