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Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates

Wai Chung Fu, Chau Ming So and Fuk Yee Kwong*

*State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, Email:

W. C. Fu, C. M. So, F. Y. Kwong, Org. Lett., 2015, 17, 5906-5909.

DOI: 10.1021/acs.orglett.5b03104


A palladium-catalyzed phosphorylation of aryl mesylates and tosylates exhibits excellent functional group compatibility - including free amino, keto, ester, and amido groups. The mesylated derivatives of biologically active compounds such as 17β-estradiol and 6-hydroxyflavone are applicable substrates too.

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ID: J54-Y2015