Imidazolium Salt Catalyzed para-Selective Halogenation of Electron-Rich Arenes
Jie Chen, Xiaoyu Xiong, Zenghua Chen, Jianhui Huang*
*School of Pharmaceutical Science and Technology, Tianjin
University, 92 Weijin Road, Nankai District, Tianjin 300072, China, Email: jhuang
tju.edu.cn
J. Chen, X. Xiong, Z. Chen, J. Huang, Synlett, 2015, 26, 2831-2834.
DOI: 10.1055/s-0035-1560376
Abstract
A highly para-selective halogenation of arenes bearing electron-donating coordinating groups in the presence of a dimidazolium salt rpovides p-haloarenes in good yields. A plausible mechanism for the catalytic reaction is proposed.
see article for more examples
Key Words
arenes, amides, ethers, regioselectivity, chlorination, bromination, iodination, NCS, NBS, NIS, organocatalysis
ID: J60-Y2015
