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NMP and O2 as Radical Initiator: Trifluoromethylation of Alkenes to Tertiary β-Trifluoromethyl Alcohols at Room Temperature

Chao Liu, Qingquan Lu, Zhiyuan Huang, Jian Zhang, Fan Liao, Pan Peng and Aiwen Lei*

*College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, P. R. China, Email:

C. Liu, Q. Lu, Z. Huang, J. Zhang, F. Liao, P. Peng, A. Lei, Org. Lett., 2015, 17, 6034-6037.

DOI: 10.1021/acs.orglett.5b03035

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Various tertiary β-trifluoromethyl alcohols can be synthesized in good yields without transition metal catalysts via a radical trifluoromethylation of alkenes using in situ generated peroxide in NMP under O2 as the radical initiator.

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Key Words

trifluormethylation, hydroxylation, oxygen

ID: J54-Y2015