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N-Substituted Formamides as C1-Sources for the Synthesis of Benzimidazole and Benzothiazole Derivatives by Using Zinc Catalysts

Deepak B. Nale, Bhalchandra M. Bhanage*

*School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China, Email:

D. B. Nale, B. M. Bhanage, Synlett, 2015, 26, 2831-2834.

DOI: 10.1055/s-0035-1560319 (free Supporting Information)

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The use of various o-phenylenediamines and N-substituted formamides as C1 sources in a zinc-catalyzed cyclization in the presence of poly(methylhydrosiloxane) provides benzimidazoles in good yields. Benzoxazole and benzothiazole derivates can also be synthesized.

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Key Words

formamides, benzenediamines, cyclizations, heterocycles, benzimidazoles, zinc, catalysis, PMHS

ID: J60-Y2015