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One-Pot Synthesis of O-Aryl Carbamates

Sami E. Varjosaari, Paolo Suating, Marc J. Adler*

*Department of Chemistry & Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115-2828, USA, Email:

S. E. Varjosaari, P. Suating, M. J. Adler, Synthesis, 2016, 48, 43-47.

DOI: 10.1055/s-0035-1560726


N-Substituted carbamoyl chlorides can be formed in situ and subsequently reacted with substituted phenols to avoid the direct manipulation of sensitive reactants. This simple, versatile, one-pot procedure for the synthesis of substituted O-aryl carbamates offers an economical and efficient route to many compounds of interest.

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Key Words

O-aryl carbamates, phenyl carbamates, carbamoylation, amination, one-pot, versatile, safe, high yield

ID: J66-Y2016